Cost vaccin tulpina hpv 16-18

against HPV types 16 and 18 pr oduced by GlaxoSmithKline. The second vaccine, Gardasil TM, is active against HPV types 6, 11, 16 and The purpose of this study was to assess the cost-effectiveness of adding vaccination with the ASadjuvanted human papillomavirus 16/18 vaccine (CervarixTM) at age 12 to the current national cervical. In , the Institute of Medicine (IOM) published a report listing 26 candidate vaccines that potentially could be developed and licensed in the first 2 decades of the 21st century ().Included in this list was a candidate vaccine for human papillomavirus (HPV), a virus that can cause cervical and other anogenital Gel Papillors, genital warts, and other adverse health outcomes (1–5). 1/1/ · This study compares vaccination of young girls with anti HPV 16/18 and anti HPV 6/11/16/18 versus no vaccination plan. The latter represents the “do nothing” option, which is the current practice in the study site (Canada).

Evidently, the status quo of service provision in the country must be assessed before trying to universalize the hpv.iubescstudentia.ro by: 2. 9/1/ · A new frontier of cervical Gel Papillor prevention began with use of human papillomavirus (HPV) vaccines, but the question is: which vaccine to choose? There are now two highly efficacious vaccines approved in many developed countries, the Merck quadrivalent HPV 6/11/16/18 (Gardisil) and the GSK bivalent HPV 16/18 (Cevarix). Many countries have committed to HPV immunisation programmes, Cited by: 3.

Cost vaccin tulpina hpv 16-18

Cost vaccin tulpina hpv 16-18
The Cost vaccin tulpina hpv 16-18 do not prevent other sexually transmitted diseases, nor do they treat existing HPV infections or HPV-caused disease. Emerging Infectious Diseases. Atlanta: Centers for Disease Control and Prevention; Medicaid covers HPV vaccination in accordance with ACIP recommendations, and immunizations are a mandatory service under Medicaid for eligible individuals under age Human papillomavirus typing in reporting of condyloma. Support Center Support Center. As the model is static, it cannot take avccin account effects on disease transmission and thus cannot Cost vaccin tulpina hpv 16-18 any level of herd protection.

Base Case Analyses Using base-case parameter values Technical Appendixwe estimated the cost-effectiveness of HPV vaccination by using 12 variations of the model. However, these women should be told that the vaccination will not cure them of current HPV infections or treat the abnormal results of their Pap test Legal Requirements. A static Markov cohort model with annual cycles was used to estimate vaccni costs and health benefits of adding HPV vaccination to screening over 95 cycles lifetime of the cohort. The most common problems have been brief soreness and other local symptoms at the injection site. But some types of HPV are known for causing Gel Papillor.
3/1/ · Therefore, our effort to develop the cost-effective trivalent HPV 16/18/58 vaccine would undoubtedly contribute to this endeavor.

This study showed that a novel trivalent HPV 16/18/58 vaccine adjuvanted with aluminum hydroxide elicited robust and durable immune responses against all three vaccine HPV types in rhesus hpv.iubescstudentia.ro by: 5. HPV vaccines are vaccines that protect against infection with human papillomaviruses (HPV). HPV is a group of more than related viruses, of which more than 40 are spread through direct sexual hpv.iubescstudentia.ro these, two HPV types cause genital warts, and about a dozen HPV types can cause certain types of Gel Papillor—cervical, anal, oropharyngeal, penile, vulvar, and vaginal. Gardasil 9 helps prevent infection by 4 types of HPV (16, 18, 6 and 11), plus 5 other high risk types: 31, 33, 45, 52 and Together these types cause about 90% of cervical Gel Papillors. Who should be vaccinated against HPV and when? HPV vaccine produces the strongest immune response in preteens.

Human Papillomavirus (HPV) Vaccines – National Gel Papillor Institute


The federal Affordable Care Act ACA requires most private insurance plans to cover recommended preventive services including HPV vaccination with no copay or deductible. Pregnant women should not get any HPV vaccine at this time, even though they appear to Cost vaccin tulpina hpv 16-18 safe for both mother and the unborn baby. Cost data are shown in Table 3. Childhood Gel Papillor Genomics. Another disadvantage of our approach is that it offers only a rough approximation of the cost-effectiveness of HPV vaccination and is not suitable for examining strategies such as vaccination of boys and men. Vaccun for incident human papillomavirus infection and low-grade Clst intraepithelial lesion development Cost vaccin tulpina hpv 16-18 young females. Manage Your Award.

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Changes in the other sets of parameter values such as costs and QALYs associated with HPV-related health outcomes also affected the results, but to a lesser degree than changes in the discount rate and time horizon Table 2. However, much of the variation in the best and worst case scenarios was attributable to changes in the discount rate and the time horizon. Estimates from the simplified model were quite consistent with published estimates Table 4. We developed a simple model to estimate the cost-effectiveness of HPV vaccination in the context of current cervical Gel Papillor screening in the United States.
Our results were consistent with results of published studies based on more complex models, particularly when key assumptions e. The simplicity of our approach offers advantages and disadvantages. The main advantage is that it requires substantially fewer assumptions than the more complex Markov and transmission models.

For example, there is no need to model the probability of HPV acquisition, the possible progression from HPV infection to disease, the mixing of sex partners, the probability of HPV transmission, and so forth.
There also is no need to model cervical Gel Papillor screening and sexually transmitted disease prevention activities because these activities are reflected in the incidence rates of HPV-related health outcomes that we applied. Because we do not model cervical Gel Papillor screening directly, however, we are unable to use our model to examine how changes in cervical Gel Papillor—screening strategies can affect the cost-effectiveness of HPV vaccination, and vice versa.

For example, HPV vaccination is expected to reduce the positive predictive value of abnormal Papanicolaou Pap test results However, our analysis did not include the loss in quality of life attributable to the initial distress associated with receiving an abnormal Pap result 39 , regardless of whether it is a false positive. This omission of the lost QALYs due to abnormal Pap test results underestimates the benefits of HPV vaccination because vaccination is expected to offer moderate reductions in the number of abnormal Pap results overall 38 , Future changes in screening strategies, such as delayed screening, could also possibly improve the cost-effectiveness of HPV vaccination Another disadvantage of our approach is that it offers only a rough approximation of the cost-effectiveness of HPV vaccination and is not suitable for examining strategies such as vaccination of boys and men.

In addition, although many of the parameter values and assumptions in our model can be modified with ease, changing the assumption of lifelong duration of protection or examining vaccination at older ages would require the incorporation of assumptions about the incidence and natural history of HPV to account for the probability of acquiring HPV before vaccination or after vaccine immunity wanes and the subsequent probability of adverse HPV-attributable health outcomes. However, we can address the issue of waning immunity by assigning a higher cost per vaccination series as in the sensitivity analyses to reflect the cost of a booster. Another limitation of our approach is the uncertainty in the key parameter values, such as the cost and loss in quality of life associated with HPV-related health outcomes, the percentage of health outcomes attributable to each type of HPV targeted by the vaccine, and the incidence of CIN and genital warts.

However, our results were fairly robust in response to changes in these key parameter values. Our adjustments for the effect of herd immunity were arbitrary; we simply assumed an additional effect of vaccination in the nonvaccinated population. However, our results did not vary substantially in absolute terms when the assumed effect of herd immunity was varied. We also note that the benefits to nonvaccinated persons were assumed to occur only in nonvaccinated persons of similar ages to those vaccinated. This restriction may have understated the potential benefits of herd immunity. Our analysis did not address all of the potential costs and benefits of vaccination.

For example, the cost-effectiveness estimates would have been more favorable to vaccination if we had included the potential for cross-protection against high-risk HPV types besides 16 and 18 21 ; the prevention of anal, vaginal, and vulvar Gel Papillor precursor lesions as demonstrated in the supplemental analysis in the Technical Appendix ; the prevention of other Gel Papillors not included in this analysis such as anal Gel Papillor and oropharyngeal Gel Papillors in male patients ; and the prevention of other HPV-related health outcomes such as recurrent respiratory papillomatosis. Conversely, the cost-effectiveness estimates would have been less favorable to vaccination if we had included the potential for HPV type replacement i.
A key finding from this analysis was that the choice of discount rate and time horizon has a substantial influence on the estimated cost-effectiveness of vaccination.

Because the costs of HPV vaccination begin to accrue immediately but the full benefits of vaccination are not realized for many years, the cost-effectiveness of vaccination becomes less favorable when higher discount rates are applied or when shorter time horizons are examined. Another key finding was that the potential benefits of preventing anal, vaginal, vulvar, and oropharyngeal Gel Papillors offer nontrivial improvements in the estimated cost-effectiveness of HPV vaccination.
Future studies that develop better estimates of the cost and loss in quality of life associated with these Gel Papillors could more accurately estimate the effects of these additional benefits on the cost-effectiveness of HPV vaccination. Despite the limitations discussed above, our simplified model provides useful estimates of cost-effectiveness of HPV vaccination in the United States. Our results were consistent with previous studies based on more complex models.

This consistency is reassuring because models of various degrees of complexity will be essential tools for policy makers in the development of optimal HPV vaccination strategies. His research interests include the impact and cost-effectiveness of STD prevention programs, alcohol and substance abuse and risky sexual behavior, and risk and uncertainty.
Table of Contents — Volume 14, Number 2—February Please use the form below to submit correspondence to the authors or contact them at the following address: Harrell W. Highlight and copy the desired format. Section Navigation. Facebook Twitter LinkedIn Syndicate. Table 1 Table 2 Table 3 Table 4. Article Metrics. Related Articles.

Abstract We describe a simplified model, based on the current economic and health effects of human papillomavirus HPV , to estimate the cost-effectiveness of HPV vaccination of year-old girls in the United States.
Population Model A hypothetical population of persons 12—99 years of age was created as follows. Vaccine Coverage, Efficacy, and Costs We assumed the HPV vaccine would be administered to year-old girls starting in year 1 and continuing through year Adverse Health Outcomes Averted by Vaccination We examined the following HPV-related health outcomes: cervical Gel Papillor; CIN grades 1, 2, and 3; genital warts; and, in some analyses, anal, vaginal, vulvar, and selected oropharyngeal Gel Papillors. Cervical Gel Papillor Screening The incidence rates of CIN and cervical Gel Papillors that we applied in our model are those that arise in the context of current cervical Gel Papillor screening and sexually transmitted disease prevention activities in the United States.

Costs Averted and QALYs Saved by Vaccination The cervical Gel Papillor treatment costs averted by vaccination were calculated each year by multiplying the age-specific number of cervical Gel Papillor cases averted by the vaccine in that year by the estimated cost per case of cervical Gel Papillor, Technical Appendix.
Herd Immunity Scenario To examine how the estimated cost-effectiveness of vaccination might change if the benefits of herd immunity were included, we assumed an additional effect of the vaccine on nonvaccinated persons, including a reduction in genital warts in men. Cohort Model To make our results more comparable to Markov models of an age cohort, we modified our population model to examine the benefits of vaccination of a single cohort of year-old girls over time. Base Case Analyses Using base-case parameter values Technical Appendix , we estimated the cost-effectiveness of HPV vaccination by using 12 variations of the model.

Sensitivity Analyses We performed sensitivity analyses to examine how changes in the base-case parameter values influenced the estimated cost-effectiveness of vaccination. Comparison to Previous Cost-Effectiveness Studies We compared our results with previously published estimates of the cost-effectiveness of HPV vaccination. Sensitivity Analyses The cost-effectiveness ratios did not change substantially when we modified the assumptions in the population model about the effect of herd immunity. Comparison with Previous Cost-Effectiveness Studies Estimates from the simplified model were quite consistent with published estimates Table 4. Institute of Medicine. Vaccines for the 21st century: a tool for decisionmaking. Washington: National Academy of Sciences; Parkin DM , Bray F.
Chapter 2: the burden of HPV-related Gel Papillors. DOI PubMed. Centers for Disease Control and Prevention.

Comparison of HPV type distribution in high-grade cervical lesions and cervical Gel Papillor: a meta-analysis. Br J Gel Papillor. Genital human papillomavirus infection. Clin Infect Dis. J Clin Microbiol. The estimated direct medical cost of sexually transmitted diseases among American youth, Perspect Sex Reprod Health. Assessing the annual economic burden of preventing and treating anogenital human papillomavirus-related disease in the US: analytic framework and review of the literature. Model for assessing human papillomavirus vaccination strategies. Emerg Infect Dis. J Natl Gel Papillor Inst. Cost-effectiveness of a potential vaccine for human papillomavirus.

Potential health and economic impact of adding a human papillomavirus vaccine to screening programs. Evaluating human papillomavirus vaccination programs. Mathematical models for predicting the epidemiologic and economic impact of vaccination against human papillomavirus infection and disease. Epidemiol Rev.
Cost-effectiveness in health and medicine. New York: Oxford University Press; Prevention effectiveness: a guide to decision analysis and economic evaluation, 2nd ed. Census Bureau.

N Engl J Med. Obstet Gynecol. Lancet Oncol. United States Gel Papillor statistics: incidence and mortality. The surveillance, epidemiology, and end results program: a national resource. Gel Papillor Epidemiol Biomarkers Prev. Leading partnerships to assess the burden of HPV-related Gel Papillors. Atlanta: Centers for Disease Control and Prevention; The obtained cost figures were provided by experts during the first meeting and thereafter discussed by all experts through e-mail exchange and finally endorsed by all experts during a second meeting.
All costs represent direct medical costs and were calculated on an annual basis for the year — Cost data are shown in Table 3. Price-per-dose parity was assumed for both vaccines.

The model uses vaccine effectiveness against CC on incident oncogenic HPV infection and vaccine effectiveness against genital warts on incident low-risk HPV infection. These were thereafter adjusted for each lesion. Vaccine efficacy data were taken from clinical trials. See Table 4 for details. For both vaccines, the analysis used data on vaccine efficacy in girls and women who were DNA-negative and seronegative for the relevant HPV type at study entry i.
These data are the most representative of vaccine efficacy among girls before the onset of sexual activity and are therefore the most relevant to the vaccination of year-old girls in the Philippines. Since country-specific utility data for the Philippines were lacking, published disutility data from other evaluations of HPV vaccination were applied in this analysis. The CC incidence was retrieved from the — Gel Papillor registry data in Manila as reported by the Philippine Gel Papillor Society.

In the base case, all costs and outcomes were estimated non-discounted and discounted at 3.
The analysis was conducted from the perspective of the Philippine government. Only direct medical costs hospitalisation, screening tests and procedures, vaccine costs were included. Incremental cost, QALY and cost-effectiveness were derived from these estimates. One-way sensitivity analyses evaluated the effect on the results of variability in the model parameters.
For the treatment cost, the government hospital cost was used as the lower limit and the cost at a private institution as the upper limit see Table 3. A specific sensitivity analysis explored the effect of using a discount rate of 1. Distributions were assigned to input parameters by using a normal distribution when confidence intervals were reported and uniform distribution when no range was available see Additional File 4 for details. A total of 10, iterations were sampled from the assigned distribution.

CP is employee of United Laboratories Inc. BC received honoraria for lectures from the GSK group of companies. GlaxoSmithKline Biologicals S. All authors participated in the design, data acquisition, and interpretation of the study and the development of this manuscript.
All authors had full access to the data and gave final approval before submission. National Center for Biotechnology Information , U. Journal List Hum Vaccin Immunother v. Hum Vaccin Immunother. Published online Jan Socorro Bernardino. Author information Article notes Copyright and License information Disclaimer. Color versions of one or more of the figures in the article can be found online at www. Supplemental data for this article can be accessed on the publisher’s website.
Copyright © The Author s. The moral rights of the named author s have been asserted.

Associated Data Supplementary Materials Supplementary files. Introduction Cervical Gel Papillor CC , with an estimated yearly incident number of 6, cases and 2, deaths year , 1 is the second most frequent Gel Papillor and the second leading cause of Gel Papillor death in the Philippines in women of all ages. Base case Table 1 shows the results of the base-case analysis. Table 1. Open in a separate window. Probabilistic sensitivity analyses The results of the probabilistic sensitivity analysis were plotted on a cost-effectiveness plane Fig.
Figure 1. Methods Model Model structure A static Markov cohort model with annual cycles was used to estimate the costs and health benefits of adding HPV vaccination to screening over 95 cycles lifetime of the cohort. Input data Philippine specific data were used wherever available.

Table 2. Transition probabilities between model health states. Health states Transition probability Source Remarks Age-specific mortality 0. The 5-year CC survival rate of metro Manila residents is The annual CC survival rate is calculated as 1— The annual CC mortality rate is calculated as 1- 1—0. Transition probabilities The transition probabilities for low-risk and oncogenic HPV infection were obtained from published sources or calibrated, 25 and are listed in Table 2.
Screening parameters Screening coverage was set at 7. Costs No published cost data were available for the Philippines. Table 3. Vaccine effectiveness The model uses vaccine effectiveness against CC on incident oncogenic HPV infection and vaccine effectiveness against genital warts on incident low-risk HPV infection. Table 4. Vaccine effectiveness against each type of lesion and disutilities.

Disutilities Since country-specific utility data for the Philippines were lacking, published disutility data from other evaluations of HPV vaccination were applied in this analysis. Cost-effectiveness analysis Discount rate In the base case, all costs and outcomes were estimated non-discounted and discounted at 3.
Perspective The analysis was conducted from the perspective of the Philippine government. Sensitivity analyses Both one-way and probabilistic sensitivity analyses were conducted. One-way sensitivity analyses One-way sensitivity analyses evaluated the effect on the results of variability in the model parameters. Probabilistic sensitivity analysis A probabilistic sensitivity analysis was conducted using Monte Carlo simulation with the software package Risk Palisade Corporation, Ithaca, NY. Supplementary Material Supplementary files: Click here to view.

Contributorship All authors participated in the design, data acquisition, and interpretation of the study and the development of this manuscript. Epidemiology, prevention and treatment of cervical Gel Papillor in the Philippines. Human papillomavirus is a necessary cause of invasive cervical Gel Papillor worldwide. Cross-roads in the classification of papillomaviruses. Biology and natural history of human papillomavirus infection.
S [ CrossRef ] [ Google Scholar ]. Human papillomavirus genotype attribution in invasive cervical Gel Papillor: a retrospective cross-sectional worldwide study. The impact of quadrivalent human papillomavirus HPV; types 6, 11, 16, and 18 L1 virus-like particle vaccine on infection and disease due to oncogenic nonvaccine HPV types in generally HPV-naive women aged 16—26 years.

Hum Vaccin Immunother ; 12 Corporation Philippines , letter to: May 6. Int J Gynecol Gel Papillor ; 19 Cost-effectiveness analysis of the bivalent compared with the quadrivalent human papillomavirus vaccines in Taiwan.
Cost-effectiveness of vaccination against cervical Gel Papillor: A multi-regional analysis assessing the impact of vaccine characteristics and alternative vaccination scenarios. Modelling the economic value of cross- and sustained-protection in vaccines against cervical Gel Papillor. Meta-analysis of Pap test accuracy. The impact of genital warts: loss of quality of life and cost of treatment in 8 sexual health clinics in the UK.
Toward consistency in cost-utility analyses: using national measures to create condition-specific values.


Cervical Gel Papillor CC is the second leading cause of Gel Papillor death among Filipino women. This study aims to evaluate the cost-effectiveness of HPV vaccination of year-old Filipino girls, in addition to current screening, in the new 2D schedule. Incremental cost, quality-adjusted life year QALY and cost-effectiveness were derived Cost vaccin tulpina hpv 16-18 these estimates. Input data were obtained from published sources and Delphi panel, using country-specific data where possible. Sensitivity analyses were performed to assess the robustness of the model.

Cervical Gel Papillor CCwith an estimated yearly incident number of 6, cases and 2, deaths year1 is the second most frequent Gel Papillor and the second leading cause of Gel Papillor death in the Philippines in Cost vaccin tulpina hpv 16-18 of all ages. Typically, the vaccine is given to girls around the age of 12 or 13 y and ideally before the onset of sexual activity and thus before first exposure to cervical HPV infection. Both vaccines were originally developed for a 3-dose 3D administration.

HPV Vaccines

Human Papillomavirus (HPV) Vaccines

HPV is a group of more than related virusesof which more than 40 are spread through direct sexual contact. Cost vaccin tulpina hpv 16-18 these, two HPV types cause genital wartsand about a dozen HPV types can cause certain types of Gel Papillor— cervicalanaloropharyngealpenilevulvarand vaginal. Three vaccines that prevent infection Cst disease-causing HPV types are licensed for use in the United States: Gardasil ®, Gardasil® 9and Cervarix ®. Cervarix and Gardasil are still used in other countries. The HPV vaccine is given as a Cost vaccin tulpina hpv 16-18 of shots.

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